Written in English
Thesis (M.D.) - University College Dublin, 1992.
|Statement||Kieran J. Crowley.|
Differing effects of various barbiturates used to induce coma. Neuwelt EA, Kikuchi K, Hill SA, Lipsky P, Frenkel E. The present studies evaluated the effect of phenobarbital, pentobarbital, and thiopental at Cited by: The action of barbiturates on the enzymatic activity of lung lipoprotein lipase has been studied in vitro and in vivo. Mouse lung preparations can be Author: G.A. Skowronski, S. Varghese, S.B. Gertner, S.I. Sherr. These effects are dependent on the duration of exposure to the barbiturate. Acutely, barbiturates interact with various CYPs and inhibit the biotransformation of other CYP substrates; likewise, other . There is evidence that barbiturates penetrate into membrane lipid and alter the physical state of the lipid. Resultant changes in ion channels and mem-brane-bound enzymes have been hypothesized as a File Size: 1MB.
Selective inhibition by barbiturates of the synthesis of endothelium-derived hyperpolarizing factor in the rabbit carotid artery. Lischke V(1), Busse R, Hecker M. Author information: (1)Centre of Physiology, Cited by: Barbiturates are classified according to their duration of action. The effects of long-acting barbiturates, such as barbital and phenobarbital, may last for as long as 24 hours; these drugs are used in . Start studying PSYCH BARBITURATES AND BENZODIAZEPENES. Learn vocabulary, terms, and more with flashcards, games, and other study tools. barbiturates and benzodiazepines. STUDY. Flashcards. Learn. Write. Spell. Test. PLAY. Match. Gravity. Created by. Scott_Thornburg. Terms in this set (13) barbiturates acute effects - drug class of sedative .
Barbiturates mechanism of action is described here. Barbiturates most likely produce their sedative hypnotic effects through an interaction with the inhibitory neurotransmitter gamma-aminobutyric acid . Barbiturates causes hepatic microsomal enzyme induction * days after sustained administration * May persists for up to 30 days * Phenobarbitone is the most potent enzyme inducer among barbiturates . ?p= Barbiturates, Mechanism, of, action, Clinical, Use, Side, Effects, phenobarbital, pentobarbital, thiopental, secobarbital. Barbiturates suppress APdepen- dent gene transcription, barbiturates inhibit PMA/ionomycin-or CD3/CDinduced AP-1 complex formation, and effects are dose-dependent and occur at clinically.